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New Tirucallane-Type Triterpenoids from Guarea guidonia.
Hernandez, Vanessa; De Leo, Marinella; Cotugno, Roberta; Braca, Alessandra; De Tommasi, Nunziatina; Severino, Lorella.
Afiliação
  • Hernandez V; Departamento de Farmacognosia y Medicamentos Organicos, Universidad de los Andes, Mérida, Venezuela.
  • De Leo M; Dipartimento di Farmacia, Università di Pisa, Italy.
  • Cotugno R; Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute," Università di Pisa, Italy.
  • Braca A; Dipartimento di Farmacia, Università di Salerno, Fisciano (SA), Italy.
  • De Tommasi N; Dipartimento di Farmacia, Università di Pisa, Italy.
  • Severino L; Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute," Università di Pisa, Italy.
Planta Med ; 84(9-10): 716-720, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29341030
ABSTRACT
The aerial parts of Guarea guidonia afforded three new tirucallane-type triterpenoids 3,4-seco-tirucalla-4(28),8(9),24(25)-trien-7α,11α-dihydroxy-21,23-epoxy-3,11-olide, named guareolide (1 ), 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21-hydroxy-21,23-epoxy-3-oic acid, named guareoic acid A (2 ), and 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21,23-epoxy-3-oic acid, named guareoic acid B (3 ), of which 1 possessed an unusual seven-membered lactone ring. Seven known terpenes were also isolated and characterized as flindissone, 7-acetyldihydronomilin, picroquassin E, boscartol C, and cneorubins A, B, and X. Their structures were determined by spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance analysis and high-resolution mass spectrometry. The isolates were investigated for their potential cytotoxic activity on Jurkat, HeLa, and MCF7 cancer cell lines. Flindissone and compound 2 showed an antiproliferative activity in all cell lines. Further studies revealed that flindissone, the most active compound, induced in Jurkat and HeLa cells both cytostatic and cytotoxic responses.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Triterpenos / Meliaceae / Proliferação de Células Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Triterpenos / Meliaceae / Proliferação de Células Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article