Risk factors and outcomes for multidrug-resistant Gram-negative bacilli bacteremia.
Ther Adv Infect Dis
; 5(1): 11-18, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29344356
ABSTRACT
BACKGROUND:
The incidence of multidrug-resistant (MDR) organisms is increasing along with mortality. Identifying risk factors for the development of MDR Gram-negative bacilli (GNB) bacteremia could greatly impact patient care and management.METHODS:
Data from the electronic health record of patients with GNB over 13-month period were collected at a single university medical center. Baseline demographic data, risk factor, microbiological data, recurrence of bacteremia, and mortality were recorded.RESULTS:
A total of 177 patients were included in the analysis. MDR GNB occurred in 46 patients (26%). The mortality rate in the MDR group was 34.8% compared to 13.7% in non-MDR group (p = 0.002). In multivariate analysis, diabetes mellitus [DM; odds ratio (OR) 2.8, 95% confidence interval (CI) 1-4.88], previous antibiotic use (OR 2.93, 95% CI 1.25-6.87), and urinary catheter as a source of infection (OR 5.96, 95% CI 1.78-19.94) were significant risk factors for the development of MDR GNB. In addition, end-stage liver disease (OR 3.64, 95% CI 1.07-12.3), solid organ malignancy (OR 3.64, 95% CI 1.25-10.56), intra-abdominal source of infection (OR 3.66, 95% CI 1.14-11.73), inappropriate empiric antibiotics (OR 7.59, 95% CI 1.68-34.34) and urinary catheter as a source of infection (OR 5.68, 95% CI 1.37-23.5) were significant factors for mortality in patients with MDR GNB.CONCLUSION:
Our study provides important information about the risk factors for the development of MDR GNB bacteremia and helps prognosticate patient with MDR GNB.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article