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The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.
Zangwill, Linda M; Ayyagari, Radha; Liebmann, Jeffrey M; Girkin, Christopher A; Feldman, Robert; Dubiner, Harvey; Dirkes, Keri A; Holmann, Matthew; Williams-Steppe, Eunice; Hammel, Naama; Saunders, Luke J; Vega, Suzanne; Sandow, Kevin; Roll, Kathryn; Slight, Rigby; Auerbach, Daniel; Samuels, Brian C; Panarelli, Joseph F; Mitchell, John P; Al-Aswad, Lama A; Park, Sung Chul; Tello, Celso; Cotliar, Jeremy; Bansal, Rajendra; Sidoti, Paul A; Cioffi, George A; Blumberg, Dana; Ritch, Robert; Bell, Nicholas P; Blieden, Lauren S; Davis, Garvin; Medeiros, Felipe A; Ng, Maggie C Y; Das, Swapan K; Palmer, Nicholette D; Divers, Jasmin; Langefeld, Carl D; Freedman, Barry I; Bowden, Donald W; Christopher, Mark A; Chen, Yii-der I; Guo, Xiuqing; Taylor, Kent D; Rotter, Jerome I; Weinreb, Robert N.
Afiliação
  • Zangwill LM; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Ayyagari R; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Liebmann JM; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Girkin CA; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Feldman R; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
  • Dubiner H; Eye Care Center Management, Inc., Marrow, Georgia.
  • Dirkes KA; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Holmann M; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Williams-Steppe E; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Hammel N; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Saunders LJ; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Vega S; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Sandow K; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Roll K; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Slight R; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Auerbach D; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Samuels BC; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Panarelli JF; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
  • Mitchell JP; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Al-Aswad LA; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
  • Park SC; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
  • Tello C; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
  • Cotliar J; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Bansal R; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Sidoti PA; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
  • Cioffi GA; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Blumberg D; Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York.
  • Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
  • Bell NP; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
  • Blieden LS; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
  • Davis G; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
  • Medeiros FA; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Das SK; Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North
  • Divers J; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Langefeld CD; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Freedman BI; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North
  • Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolin
  • Christopher MA; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance, California.
  • Weinreb RN; Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California. Electronic address: rweinreb@ucsd.edu.
Ophthalmology ; 126(1): 156-170, 2019 01.
Article em En | MEDLINE | ID: mdl-29361356
ABSTRACT

PURPOSE:

To describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III.

DESIGN:

Cross-sectional, case-control study.

PARTICIPANTS:

Three thousand two hundred sixty-six glaucoma patients and control participants without glaucoma of African or European descent were recruited from 5 study centers in different regions of the United States.

METHODS:

Individuals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and control participants completed a detailed demographic and medical history interview. Standardized height, weight, and blood pressure measurements were obtained. Saliva and blood samples to provide serum, plasma, DNA, and RNA were collected for standardized processing. Visual fields, stereoscopic disc photographs, and details of the ophthalmic examination were obtained and transferred to the University of California, San Diego, Data Coordinating Center for standardized processing and quality review. MAIN OUTCOME

MEASURES:

Participant gender, age, race, body mass index, blood pressure, history of smoking and alcohol use in POAG patients and control participants were described. Ophthalmic measures included intraocular pressure, visual field mean deviation, central corneal thickness, glaucoma medication use, or past glaucoma surgery. Ocular conditions, including diabetic retinopathy, age-related macular degeneration, and past cataract surgery, were recorded.

RESULTS:

The 3266 ADAGES III study participants in this report include 2146 AD POAG patients, 695 ED POAG patients, 198 AD control participants, and 227 ED control participants. The AD POAG patients and control participants were significantly younger (both, 67.4 years) than ED POAG patients and control participants (73.4 and 70.2 years, respectively). After adjusting for age, AD POAG patients had different phenotypic characteristics compared with ED POAG patients, including higher intraocular pressure, worse visual acuity and visual field mean deviation, and thinner corneas (all P < 0.001). Family history of glaucoma did not differ between AD and ED POAG patients.

CONCLUSIONS:

With its large sample size, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control participants from different regions in the United States, the ADAGES III genomics study will address gaps in our knowledge of the genetics of POAG in this high-risk population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Negro ou Afro-Americano / Glaucoma de Ângulo Aberto / Polimorfismo de Nucleotídeo Único Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Negro ou Afro-Americano / Glaucoma de Ângulo Aberto / Polimorfismo de Nucleotídeo Único Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article