Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin &#945;IIb ß3 binding in human platelets.

Hsia, Chih-Hsuan; Lu, Wan-Jung; Lin, Kuan-Hung; Chou, Duen-Suey; Geraldine, Pitchairaj; Jayakuma, Thanasekaran; Chang, Nen-Chung; Sheu, Joen-Rong

Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin α_II_b ß₃ binding in human platelets.

Hsia, Chih-Hsuan; Lu, Wan-Jung; Lin, Kuan-Hung; Chou, Duen-Suey; Geraldine, Pitchairaj; Jayakuma, Thanasekaran; Chang, Nen-Chung; Sheu, Joen-Rong.

Afiliação

Hsia CH; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lu WJ; Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.
Lin KH; Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chou DS; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Geraldine P; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Jayakuma T; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chang NC; Department of Cardiology, Taipei Medical University Hospital, Taipei, Taiwan.
Sheu JR; Graduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.

J Cell Mol Med ; 22(4): 2142-2152, 2018 04.

Article em En | MEDLINE | ID: mdl-29369482

Assuntos

Antineoplásicos/farmacologia; Plaquetas/metabolismo; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Fibrinogênio/metabolismo; Complexo Glicoproteico GPIIb-IIIa de Plaquetas/metabolismo; Trifosfato de Adenosina/metabolismo; Adulto; Coagulação Sanguínea/efeitos dos fármacos; Plaquetas/efeitos dos fármacos; Compostos Bicíclicos Heterocíclicos com Pontes/química; Adesão Celular/efeitos dos fármacos; Ativação Enzimática/efeitos dos fármacos; Proteína-Tirosina Quinases de Adesão Focal/metabolismo; Humanos; L-Lactato Desidrogenase/metabolismo; Selectina-P/metabolismo; Adesividade Plaquetária/efeitos dos fármacos; Agregação Plaquetária/efeitos dos fármacos; Substâncias Protetoras/química; Substâncias Protetoras/farmacologia; Ligação Proteica/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Trombose/patologia

Palavras-chave

antithrombosis; fibrinogen; integrin αIIbß3; norcantharidin; platelet aggregation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Fibrinogênio / Complexo Glicoproteico GPIIb-IIIa de Plaquetas / Compostos Bicíclicos Heterocíclicos com Pontes / Antineoplásicos Limite: Adult / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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