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iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Melguizo-Sanchis, Dario; Xu, Yaobo; Taheem, Dheraj; Yu, Min; Tilgner, Katarzyna; Barta, Tomas; Gassner, Katja; Anyfantis, George; Wan, Tengfei; Elango, Ramu; Alharthi, Sameer; El-Harouni, Ashraf A; Przyborski, Stefan; Adam, Soheir; Saretzki, Gabriele; Samarasinghe, Sujith; Armstrong, Lyle; Lako, Majlinda.
Afiliação
  • Melguizo-Sanchis D; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Xu Y; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Taheem D; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Yu M; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Tilgner K; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Barta T; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Gassner K; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Anyfantis G; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
  • Wan T; The Ageing Biology Centre. Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, UK.
  • Elango R; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Alharthi S; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
  • El-Harouni AA; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Przyborski S; Department of Bioscience, Durham University, Durham, UK.
  • Adam S; Hematology Department, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Saretzki G; Department of Medicine, Duke University Medical Center, Durham, USA.
  • Samarasinghe S; The Ageing Biology Centre. Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, UK.
  • Armstrong L; Department of Hematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Lako M; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
Cell Death Dis ; 9(2): 128, 2018 01 26.
Article em En | MEDLINE | ID: mdl-29374141
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Diferenciação Celular / Células-Tronco Pluripotentes Induzidas / Encurtamento do Telômero / Anemia Aplástica / Modelos Biológicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Diferenciação Celular / Células-Tronco Pluripotentes Induzidas / Encurtamento do Telômero / Anemia Aplástica / Modelos Biológicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article