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Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.
Thu, K L; Silvester, J; Elliott, M J; Ba-Alawi, W; Duncan, M H; Elia, A C; Mer, A S; Smirnov, P; Safikhani, Z; Haibe-Kains, B; Mak, T W; Cescon, D W.
Afiliação
  • Thu KL; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Silvester J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Elliott MJ; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Ba-Alawi W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Duncan MH; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Elia AC; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Mer AS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Smirnov P; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 1L7.
  • Safikhani Z; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Mak TW; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
  • Cescon DW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
Proc Natl Acad Sci U S A ; 115(7): E1570-E1577, 2018 02 13.
Article em En | MEDLINE | ID: mdl-29378962
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Neoplasias de Mama Triplo Negativas / Ciclossomo-Complexo Promotor de Anáfase Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Neoplasias de Mama Triplo Negativas / Ciclossomo-Complexo Promotor de Anáfase Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article