Detection of early cartilage damage: feasibility and potential of gagCEST imaging at 7T.
Eur Radiol
; 28(7): 2874-2881, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29383528
ABSTRACT
OBJECTIVES:
The purpose was to implement a fast 3D glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) sequence at 7 T, test stability and reproducibility in cartilage in the knee in healthy volunteers, and evaluate clinical applicability in cartilage repair patients.METHODS:
Experiments were carried out on a 7-T scanner using a volume transmit coil and a 32-channel receiver wrap-around knee coil. The 3D gagCEST measurement had an acquisition time of 7 min. Signal stability and reproducibility of the GAG effect were assessed in eight healthy volunteers. Clinical applicability of the method was demonstrated in five patients before cartilage repair surgery.RESULTS:
Coefficient of variation of the gagCEST signal was 1.9%. The reproducibility of the GAG effect measurements was good in the medial condyle (ICC = 0.87) and excellent in the lateral condyle (ICC = 0.97). GAG effect measurements in healthy cartilage ranged from 2.6%-12.4% compared with 1.3%-5.1% in damaged cartilage. Difference in GAG measurement between healthy cartilage and damaged cartilage was significant (p < 0.05).CONCLUSIONS:
A fast 3D gagCEST sequence was applied at 7 T for use in cartilage in the knee, acquired within a clinically feasible scan time of 7 min. We demonstrated that the method has high stability, reproducibility and clinical applicability. KEY POINTS ⢠gagCEST measurements are stable and reproducible ⢠A non-invasive GAG measurement with gagCEST can be acquired in 7 min ⢠gagCEST is able to discriminate between healthy and damaged cartilage.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Cartilagem Articular
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Doenças das Cartilagens
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Glicosaminoglicanos
Tipo de estudo:
Diagnostic_studies
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Evaluation_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article