An intramolecular oxa-Michael reaction on α,ß-unsaturated α-amino-δ-hydroxycarboxylic acid esters. Synthesis of functionalized 1,3-dioxanes.
Org Biomol Chem
; 16(8): 1277-1286, 2018 02 21.
Article
em En
| MEDLINE
| ID: mdl-29384169
ABSTRACT
A highly diastereoselective intramolecular oxa-Michael reaction on α,ß-unsaturated α-amino-δ-hydroxycarboxylic acid esters is presented; 1,3-dioxanes functionalized in positions 2,4 and 6 were obtained in good yields and with excellent selectivities; an experimental and computational study was carried out to understand the reaction course in terms of yields and selectivities. This reaction proceeds under mild reaction conditions using highly electrophilic aldehydes and ketones.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
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Article