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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
DeWaal, Dannielle; Nogueira, Veronique; Terry, Alexander R; Patra, Krushna C; Jeon, Sang-Min; Guzman, Grace; Au, Jennifer; Long, Christopher P; Antoniewicz, Maciek R; Hay, Nissim.
Afiliação
  • DeWaal D; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Nogueira V; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Terry AR; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Patra KC; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Jeon SM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
  • Guzman G; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Au J; College of Pharmacy, Ajou University Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-749, Korea.
  • Long CP; Department of Pathology, College of Medicine, Cancer Center, University of Illinois Hospital and Health Science Chicago, Chicago, IL, 60612, USA.
  • Antoniewicz MR; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA.
  • Hay N; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA.
Nat Commun ; 9(1): 446, 2018 01 31.
Article em En | MEDLINE | ID: mdl-29386513
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Terapia de Alvo Molecular / Hexoquinase / Neoplasias Hepáticas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Terapia de Alvo Molecular / Hexoquinase / Neoplasias Hepáticas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article