ProForma: A Standard Proteoform Notation.
J Proteome Res
; 17(3): 1321-1325, 2018 03 02.
Article
em En
| MEDLINE
| ID: mdl-29397739
ABSTRACT
The Consortium for Top-Down Proteomics (CTDP) proposes a standardized notation, ProForma, for writing the sequence of fully characterized proteoforms. ProForma provides a means to communicate any proteoform by writing the amino acid sequence using standard one-letter notation and specifying modifications or unidentified mass shifts within brackets following certain amino acids. The notation is unambiguous, human-readable, and can easily be parsed and written by bioinformatic tools. This system uses seven rules and supports a wide range of possible use cases, ensuring compatibility and reproducibility of proteoform annotations. Standardizing proteoform sequences will simplify storage, comparison, and reanalysis of proteomic studies, and the Consortium welcomes input and contributions from the research community on the continued design and maintenance of this standard.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
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Processamento de Proteína Pós-Traducional
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Biologia Computacional
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Proteoma
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Proteômica
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Espectrometria de Massas em Tandem
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article