Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells.
J Nat Prod
; 81(3): 634-640, 2018 03 23.
Article
em En
| MEDLINE
| ID: mdl-29400463
ABSTRACT
HCT116 colorectal cancer cell sensitivity to peloruside A (PLA) in normoxia is not altered by hypoxia preconditioning of the cells. We examined whether the PLA effects were altered in hypoxia and whether the activity was dependent on p53. The cytotoxicity of PLA in wild-type HCT116 cells was largely unaffected by hypoxia; however, cells in which p53 was knocked out showed resistance. Knockout of the p21 gene had little effect on the activity of PLA in hypoxia. It was concluded that the response of cells to the microtubule-stabilizing agent PLA under hypoxic conditions is a p53-dependent process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Proteína Supressora de Tumor p53
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Morte Celular
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Compostos Bicíclicos Heterocíclicos com Pontes
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Lactonas
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Hipóxia
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article