Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration.
Comp Immunol Microbiol Infect Dis
; 56: 30-33, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29406280
ABSTRACT
The red-legged partridge (Alectoris rufa) is a competent host for West Nile virus (WNV) replication and highly susceptible to WNV disease. With the aim to assess in this species whether the inoculation of non-structural protein NS1 from WNV elicits a protective immune response against WNV infection, groups of partridges were inoculated with recombinant NS1 (NS1 group) or an unrelated recombinant protein (mock group), and challenged with infectious WNV. A third group received no inoculation prior to challenge (challenge group). The NS1 group failed to elicit detectable antibodies to NS1 while in the mock group a specific antibody response was observed. Moreover, no protection against WNV disease was observed in the NS1 group, but rather, it showed significantly higher viral RNA load and delayed neutralizing antibody response, and suffered a more severe clinical disease, which resulted in higher mortality. This adverse effect has not been observed before and warrants further investigations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre do Nilo Ocidental
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Vírus do Nilo Ocidental
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Doenças das Aves
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Proteínas não Estruturais Virais
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Galliformes
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article