Argentinean recommendations on the identification of treatment failure in relapsing remitting multiple sclerosis patients.
J Neurol Sci
; 385: 217-224, 2018 02 15.
Article
em En
| MEDLINE
| ID: mdl-29406907
ABSTRACT
One of the biggest challenges in multiple sclerosis (MS) is the definition of treatment response/failure in order to optimize treatment decisions in affected patients. The objective of this consensus was to review how disease activity should be assessed and to propose recommendations on the identification of treatment failure in RRMS patients in Argentina. METHODS:
A panel of experts in neurology from Argentina, dedicated to the diagnosis and care of MS patients, gathered both virtually and in person during 2016 and 2017 to carry out a consensus recommendation on the identification of treatment failure in RRMS patients. To achieve consensus, the methodology of "formal consensus-RAND/UCLA method" was used.RESULTS:
Recommendations were established based on published evidence and the expert opinion. Recommendations focused on disease management, disease activity markers and treatment failure identification were determined. Main consensus were ≥2 relapses during the first year of treatment and/or ≥3 new or enlarged T2 or T1 GAD+ lesions and/or sustained increase of ≥2 points in EDSS or ≥100% in T25FW defines treatment failure in RRMS patients.CONCLUSIONS:
The recommendations of this consensus guidelines attempts to optimize the health care and management of patients with MS in Argentina.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Falha de Tratamento
/
Esclerose Múltipla Recidivante-Remitente
/
Consenso
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article