Measurement of respiratory function decline in patients with Duchenne muscular dystrophy: a conjoint analysis.
Neurodegener Dis Manag
; 8(2): 89-96, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29412787
ABSTRACT
AIM:
In Duchenne muscular dystrophy (DMD), little attention has been paid to severity of respiratory function decline (RFD) based on disease progression. We performed a conjoint analysis among 123 Italian clinicians to generate a scale for RFD in DMD patients.METHODS:
Before the interview, 11 attributes were selected by discussion among experts. 32 'patient profiles' were generated. Each physician assessed the severity of RFD for each profile. Each level/attribute was assigned an estimated usefulness to understand its impact on RFD.RESULTS:
The identified attributes were forced vital capacity, forced vital capacity decline, dysphagia, type of ventilation and peak cough flow. These results allowed the development of a scale for RFD severity.CONCLUSION:
This scale can stratify DMD patients according to the severity of their RFD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Respiratórios
/
Distrofia Muscular de Duchenne
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article