Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.

Haines, Corinne; Elcombe, Barbara M; Chatham, Lynsey R; Vardy, Audrey; Higgins, Larry G; Elcombe, Clifford R; Lake, Brian G

Haines, Corinne; Elcombe, Barbara M; Chatham, Lynsey R; Vardy, Audrey; Higgins, Larry G; Elcombe, Clifford R; Lake, Brian G.

Afiliação

Haines C; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom.
Elcombe BM; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom.
Chatham LR; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom.
Vardy A; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom. Electronic address: audrey.vardy@conceptlifesciences.com.
Higgins LG; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom.
Elcombe CR; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom.
Lake BG; Concept Life Sciences (formerly CXR Biosciences Ltd.), 2, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, United Kingdom; Centre for Toxicology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.

Toxicology ; 396-397: 23-32, 2018 03 01.

Article em En | MEDLINE | ID: mdl-29425889

Assuntos

Hepatócitos/efeitos dos fármacos; Hipnóticos e Sedativos/farmacologia; Fenobarbital/farmacologia; Receptores Citoplasmáticos e Nucleares/efeitos dos fármacos; Receptores de Esteroides/efeitos dos fármacos; Animais; Células Cultivadas; Receptor Constitutivo de Androstano; Citocromos/metabolismo; Replicação do DNA/efeitos dos fármacos; Fator de Crescimento Epidérmico/metabolismo; Feminino; Humanos; Hipnóticos e Sedativos/sangue; Fígado/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Tamanho do Órgão; Fenobarbital/sangue; Receptor de Pregnano X; Ratos; Ratos Sprague-Dawley

Palavras-chave

Constitutive androstane receptor; Cultured hepatocytes; Pregnane X receptor; Replicative DNA synthesis; Sodium phenobarbital; hCAR/hPXR mice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenobarbital / Receptores de Esteroides / Receptores Citoplasmáticos e Nucleares / Hepatócitos / Hipnóticos e Sedativos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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