Anti-HBs Titers Following Pentavalent Immunization (DTwP-HBV-Hib) in Term Normal Weight vs Low Birthweight Infants.
Indian Pediatr
; 55(5): 395-399, 2018 May 15.
Article
em En
| MEDLINE
| ID: mdl-29428913
ABSTRACT
OBJECTIVE:
To compare anti-HBs titers between term low birth weight (1800-2499 g) infants and normal birthweight infants, 6 weeks after last dose of primary immunization with pentavalent vaccine, and to study adverse events following immunization (AEFI) with pentavalent vaccine.DESIGN:
Cohort study.SETTING:
Tertiary-care hospital predominantly catering to urban poor population of East Delhi.PARTICIPANTS:
265 low birthweight (1800-2499 g) and 265 normal birthweight (2500-4000 g) infants. Monovalent Hepatitis B vaccine was administered within 24 hours of birth followed by three primary doses of pentavalent vaccine at 6, 10 and 14 weeks. Anti-HBs titers were estimated after 6 weeks of third dose of pentavalent vaccine. Adverse events following immunization (AEFI) month were observed for a month after each dose of pentavalent vaccine. MAIN OUTCOMEMEASURES:
Anti HBs antibody titers after 6 weeks of primary immunization, and AEFI.RESULTS:
443 (83.5%) infants (225 low birthweight and 218 normal birthweight infants) completed the follow-up. Seroprotection against hepatitis B virus was achieved in both groups after pentavalent vaccine administration. Anti HBs GMTs in low birthweight infants (194.8 mIU/mL) and normal birthweight infants (204.2 mIU/mL) were comparable (P = 0.17). No serious adverse events were observed in either group.CONCLUSIONS:
Three primary doses of pentavalent vaccine administered along with zero dose of Hepatitis B vaccine at birth provide good seroprotection. The vaccine appears to be safe in both low birth weight and normal birthweight infants born at term.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso ao Nascer
/
Recém-Nascido de Baixo Peso
/
Vacina contra Difteria, Tétano e Coqueluche
/
Vacinas contra Hepatite B
/
Vacinas Anti-Haemophilus
/
Imunogenicidade da Vacina
/
Anticorpos Anti-Hepatite B
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article