[DRESS syndrome secondary to pyrazinamide: An uncommon complication of tuberculosis treatment]. / DRESS syndrome au pyrazinamide : complication rare et grave du traitement antituberculeux.
Rev Mal Respir
; 35(1): 69-73, 2018 Jan.
Article
em Fr
| MEDLINE
| ID: mdl-29429561
ABSTRACT
INTRODUCTION:
The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe drug-induced reaction. CASE REPORT We report the case of a 35-year-old man treated by RHEZ for a first episode of a smear positive pulmonary tuberculosis and who developed a DRESS syndrome due to pyrazinamide after twenty days of treatment, associated with a viral reactivation to Human Herpes Virus 6 (HHV6). He had a skin eruption, liver involvement and hypereosinophilia. He fully recovered after drug withdrawal, associated with local and general corticosteroids. He died two weeks after discharge.CONCLUSIONS:
Discovery of DRESS syndrome during tuberculosis treatment is an uncommon complication and requires a searching for the responsible drug. That should be difficult because tuberculosis drugs are often given as fixed-dose combination. Physicians have to bear in mind the potential role of pyrazinamide.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinamida
/
Tuberculose Pulmonar
/
Síndrome de Hipersensibilidade a Medicamentos
/
Antituberculosos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
Fr
Ano de publicação:
2018
Tipo de documento:
Article