Non-IgE mediated mast cell activation.
Immunol Rev
; 282(1): 87-113, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29431205
ABSTRACT
Mast cells (MCs) are innate immune cells that are scattered in tissues throughout the organism being particularly abundant at sites exposed to the environment such as the skin and mucosal surfaces. Generally known for their role in IgE-mediated allergies, they have also important functions in the maintenance of tissue integrity by constantly sensing their microenvironment for signals by inflammatory triggers that can comprise infectious agents, toxins, hormones, alarmins, metabolic states, etc. When triggered their main function is to release a whole set of inflammatory mediators, cytokines, chemokines, and lipid products. This allows them to organize the ensuing innate immune and inflammatory response in tight coordination with resident tissue cells, other rapidly recruited immune effector cells as well as the endocrine and exocrine systems of the body. To complete these tasks, MCs are endowed with a large repertoire of receptors allowing them to respond to multiple stimuli or directly interact with other cells. Here we review some of the receptors expressed on MCs (ie, receptors for Immunoglobulins, pattern recognition receptors, nuclear receptors, receptors for alarmins, and a variety of other receptors) and discuss their functional implication in the immune and inflammatory response focusing on non-IgE-mediated activation mechanisms.
Palavras-chave
ATP; CD151; CD37; CD48; CD53; CD63; CD81; CD9; Fc receptor; GPCR; IL-1; IL-33; MAS-related GPCR; PPAR; Toll-like receptor; alarmins; aryl hydrocarbon receptor; complement; endothelin receptors; free light chain; glucocorticoid receptor; integrins; mast cell; neuropeptides; neurotensin; nucleotide oligomerization domain-like receptors; pattern recognition receptor; retinoic acid-inducible gene-I-like receptors; sphingosine-1 phosphate; substance P; vitamin D receptor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Fc
/
Receptores Citoplasmáticos e Nucleares
/
Receptores de Reconhecimento de Padrão
/
Mastócitos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article