Ni-Catalyzed Electrochemical Decarboxylative C-C Couplings in Batch and Continuous Flow.
Org Lett
; 20(5): 1338-1341, 2018 03 02.
Article
em En
| MEDLINE
| ID: mdl-29431449
ABSTRACT
An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant. This decarboxylative C(sp3)-C(sp2) bond-forming transformation exhibits excellent substrate generality and functional group compatibility. An operationally simple continuous-flow version of this transformation using a commercial electrochemical flow reactor represents a robust and scalable synthesis of value added coupling process.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article