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Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties.
Kalvass, J Cory; Phipps, Colin; Jenkins, Gary J; Stuart, Patricia; Zhang, Xiaomei; Heinle, Lance; Nijsen, Marjoleen J M A; Fischer, Volker.
Afiliação
  • Kalvass JC; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois j.kalvass@abbvie.com.
  • Phipps C; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Jenkins GJ; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Stuart P; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Zhang X; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Heinle L; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Nijsen MJMA; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
  • Fischer V; Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois.
Drug Metab Dispos ; 46(4): 458-469, 2018 04.
Article em En | MEDLINE | ID: mdl-29437872
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligação Proteica / Proteínas Sanguíneas Limite: Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligação Proteica / Proteínas Sanguíneas Limite: Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article