[Identification of Methamphetamine Abuse and Selegiline Useï¼ Chiral Analysis of Methamphetamine and Amphetamine in Urine].
Fa Yi Xue Za Zhi
; 33(6): 599-603, 2017 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-29441766
ABSTRACT
OBJECTIVES:
To study the content variation of selegiline and its metabolites in urine, and based on actual cases, to explore the feasibility for the identification of methamphetamine abuse and selegiline use by chiral analysis.METHODS:
The urine samples were tested by chiral separation and LC-MS/MS method using CHIROBIOTIC™ V2 chiral liquid chromatography column. The chiral analysis of methamphetamine and amphetamine were performed on the urine samples from volunteers of selegiline use and drug addicts whom suspected taking selegiline.RESULTS:
After 5 mg oral administration, the positive test time of selegiline in urine was less than 7 h. The mass concentrations of Rï¼-ï¼-methamphetamine and Rï¼-ï¼-amphetamine in urine peaked at 7 h which were 0.86 µg/mL and 0.18 µg/mL and couldn't be detected after 80 h and 168 h, respectively. The sources of methamphetamine and amphetamine in the urine from the drug addicts whom suspected taking selegiline were analysed successfully by present method.CONCLUSIONS:
The chiral analysis of methamphetamine and amphetamine, and the determination of selegiline's metabolites can be used to distinguish methamphetamine abuse from selegiline use.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selegilina
/
Anfetamina
/
Estimulantes do Sistema Nervoso Central
/
Metanfetamina
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article