[Genetic Polymorphism of 30 InDel Loci in Han Population from Jiangsu Province].
Fa Yi Xue Za Zhi
; 33(6): 611-614, 2017 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-29441769
ABSTRACT
OBJECTIVES:
To investigate the genetic information of 30 insertion/deletion ï¼InDelï¼ loci in Han population from Jiangsu Province, and to explore the application values of Investigator® DIPplex kit for guiding the forensic analysis in Han population from Jiangsu Province.METHODS:
The autosomal InDel loci of 305 unrelated healthy Han individuals from Jiangsu Province were genotyped and analysed by Investigator® DIPplex kit, and the allelic frequencies and forensic parameters of 30 InDel loci were statistically analysed.RESULTS:
The distribution of 30 InDel loci in Han population from Jiangsu Province conformed to Hardy-Weinberg equilibrium. The minor allele frequencies of 21 InDel loci were above 0.3. The polymorphism information content ranged from 0.089 to 0.375, while the discrimination power distributed from 0.093 to 0.500. The paternity exclusion in duo cases and trio cases were 0.047-0.250 and 0.046-0.219, respectively. The linkage disequilibrium analysis of 30 InDel loci showed that all loci were independent from each other. The combined discrimination power was 1-7.369×10â»8, whereas the combined mean exclusion chance in duo cases was 0.998 933 978, in trio cases was 0.997 806 392. The Fst values were all less than 0.06 except HLD118 and other four loci, which showed small differences between groups.CONCLUSIONS:
The InDel loci of Investigator® DIPplex kit can be used as complementary genetic markers for the cases associated with forensic genetics.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Desequilíbrio de Ligação
/
Povo Asiático
/
Mutação INDEL
/
Genética Populacional
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article