ATP binding cassette subfamily A member 7 rs3764650 polymorphism and the risk of Alzheimer's disease.

ABSTRACT

We did a meta-analysis to assess the association between ABCA7 rs3764650 polymorphism and the risk of Alzheimer's Disease (AD). A total of 10 eligible studies with 20511 patients and 40503 controls met the inclusion criteria. ABCA7 rs3764650 polymorphism was significantly associated with AD risk (OR=1.21, 95% CI 1.16-1.26, P<0.00001; I2=5%). In the subgroup analysis by race, statistically significant associations were found in Asians (OR=1.09, 95% CI 1.01-1.18, P =0.03; I2=0%) and in Caucasians (OR=1.25, 95% CI 1.19-1.31, P<0.00001; I2=0%). In conclusion, this meta-analysis suggested that ABCA7 rs3764650 polymorphism is significantly associated with AD risk.