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Acute myeloid leukemia in a father and son with a germline mutation of ASXL1.
Seiter, Karen; Htun, Kyaw; Baskind, Paul; Liu, Zach.
Afiliação
  • Seiter K; 1Department of Medicine, New York Medical College, Valhalla, USA.
  • Htun K; 1Department of Medicine, New York Medical College, Valhalla, USA.
  • Baskind P; 1Department of Medicine, New York Medical College, Valhalla, USA.
  • Liu Z; Emerge Laboratories, Suffern, USA.
Biomark Res ; 6: 7, 2018.
Article em En | MEDLINE | ID: mdl-29456859
BACKGROUND: Myelodysplastic syndromes and acute myeloid leukemia usually occur sporadically in older adults. More recently cases of familial acute myeloid leukemia and/or myelodysplastic syndrome have been reported. CASE PRESENTATION: Currently we report a father and son who both developed myelodysplastic syndrome that progressed to acute myeloid leukemia. Both patients were found to have the identical mutation of ASXL1 on nextgen sequencing of both hematologic and nonhematologic tissues. CONCLUSIONS: These cases support the diagnosis of a germline mutation of ASXL1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article