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Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
Lin, Jun; Liu, Yiming; Wu, Hao; Huang, Zhihai; Ma, Jingfan; Guo, Chang; Gao, Feng; Jin, Peipei; Wei, Pengfei; Zhang, Yunjiao; Liu, Liu; Zhang, Rui; Qiu, Longxin; Gu, Ning; Wen, Longping.
Afiliação
  • Lin J; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Liu Y; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Wu H; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
  • Huang Z; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
  • Ma J; Department of Biological Science and Technology, School of Life Sciences, Longyan University, Longyan, Fujian, 364012, China.
  • Guo C; Department of Biological Science and Technology, School of Life Sciences, Longyan University, Longyan, Fujian, 364012, China.
  • Gao F; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Jin P; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Wei P; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Zhang Y; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Liu L; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Zhang R; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  • Qiu L; Department of Biological Science and Technology, School of Life Sciences, Longyan University, Longyan, Fujian, 364012, China.
  • Gu N; State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
  • Wen L; The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Small ; 14(13): e1703711, 2018 03.
Article em En | MEDLINE | ID: mdl-29457340
ABSTRACT
Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)-induced cytoprotective autophagy required TFEB is shown. Ag NPs-induced nucleus translocation of TFEB through a well-established mechanism involving dephosphorylation of TFEB at serine-142 and serine-211 but independent of both the mTORC1 and ERK1/2 pathways. TFEB nucleus translocation precedes autophagy induced by Ag NPs and leads to enhanced expression of autophagy-essential genes. Knocking down the expression of TFEB attenuates the autophagy induction is demonstrated, and in the meantime, enhanced cell killing in HeLa cells treats with Ag NPs, indicating that TFEB is the key mediator for Ag NPs-induced cytoprotective autophagy. The results pinpoint TFEB as a potential target for developing more effective Ag NPs-based cancer therapeutics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Autofagia / Núcleo Celular / Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos / Nanopartículas Metálicas Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Autofagia / Núcleo Celular / Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos / Nanopartículas Metálicas Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article