Identifying the favored mutation in a positive selective sweep.
Nat Methods
; 15(4): 279-282, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29457793
ABSTRACT
Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (â¼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Amplificação de Ácido Nucleico
/
Genômica
/
Hibridização de Ácido Nucleico
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article