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Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Volpi, Simona; Bult, Carol J; Chisholm, Rex L; Deverka, Patricia A; Ginsburg, Geoffrey S; Jacob, Howard J; Kasapi, Melpomeni; McLeod, Howard L; Roden, Dan M; Williams, Marc S; Green, Eric D; Rodriguez, Laura Lyman; Aronson, Samuel; Cavallari, Larisa H; Denny, Joshua C; Dressler, Lynn G; Johnson, Julie A; Klein, Teri E; Leeder, J Steven; Piquette-Miller, Micheline; Perera, Minoli; Rasmussen-Torvik, Laura J; Rehm, Heidi L; Ritchie, Marylyn D; Skaar, Todd C; Wagle, Nikhil; Weinshilboum, Richard; Weitzel, Kristin W; Wildin, Robert; Wilson, John; Manolio, Teri A; Relling, Mary V.
Afiliação
  • Volpi S; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Bult CJ; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine, USA.
  • Chisholm RL; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Deverka PA; American Institutes for Research, Washington, DC, USA.
  • Ginsburg GS; Duke Center for Applied Genomic and Precision Medicine, Duke University, Durham, North Carolina, USA.
  • Jacob HJ; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
  • Kasapi M; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • McLeod HL; DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA.
  • Roden DM; Department of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Williams MS; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania, USA.
  • Green ED; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Rodriguez LL; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Aronson S; Partners Healthcare, Cambridge, Massachusetts, USA.
  • Cavallari LH; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, Florida, USA.
  • Denny JC; Departments of Biomedical Informatics and Medicine, Vanderbilt University, Nashville, Tennessee, USA.
  • Dressler LG; Mission Health, Personalized Medicine Program, Asheville, North Carolina, USA.
  • Johnson JA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, Florida, USA.
  • Klein TE; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Leeder JS; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Missouri, USA.
  • Piquette-Miller M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Perera M; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Rehm HL; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Ritchie MD; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Skaar TC; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Wagle N; Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Weinshilboum R; Department of Molecular Pharmacology and Experimental Therapeutics and Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Weitzel KW; Department of Pharmacotherapy & Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA.
  • Wildin R; Departments of Pathology and Laboratory Medicine, and Pediatrics, University of Vermont Medical Center, Burlington, Vermont, USA.
  • Wilson J; Optum, Eden Prairie, Minnesota, USA.
  • Manolio TA; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Relling MV; Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Clin Pharmacol Ther ; 103(5): 778-786, 2018 05.
Article em En | MEDLINE | ID: mdl-29460415
ABSTRACT
Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética Tipo de estudo: Prognostic_studies / Qualitative_research / Sysrev_observational_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética Tipo de estudo: Prognostic_studies / Qualitative_research / Sysrev_observational_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2018 Tipo de documento: Article