The cycling gonad: retinoic-acid synthesis and degradation patterns during adult zebrafish Danio rerio oogenesis.
J Fish Biol
; 92(4): 1051-1064, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29465800
ABSTRACT
The expression pattern of genes coding for enzymes of the retinoic acid (RA) synthetic and degradation pathways was characterized in adult female zebrafish Danio rerio. Females were conditioned until maturation and post-spawn expression dynamics were determined. A striking upregulation of cyp26b1, but not cyp26a1, was observed following egg deposition, decreasing to initial levels during recovery. A similar, yet lower, fluctuation was observed for aldh1a2 and rdh10a, the enzymes participating in the two-step RA biosynthesis cascade. The present work highlights the dynamics of the adult D. rerio oogenesis and uncovers novel, yet elusive, metabolic contributors. Possible compartmentalized roles for the different gene paralogue isoforms are discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oogênese
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Tretinoína
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Peixe-Zebra
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Proteínas de Peixe-Zebra
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Retinal Desidrogenase
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Gônadas
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article