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Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.
Altindis, Emrah; Cai, Weikang; Sakaguchi, Masaji; Zhang, Fa; GuoXiao, Wang; Liu, Fa; De Meyts, Pierre; Gelfanov, Vasily; Pan, Hui; DiMarchi, Richard; Kahn, C Ronald.
Afiliação
  • Altindis E; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
  • Cai W; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
  • Sakaguchi M; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
  • Zhang F; Department of Metabolic Medicine, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556 Kumamoto, Japan.
  • GuoXiao W; Department of Chemistry, Indiana University, Bloomington, IN 47405.
  • Liu F; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
  • De Meyts P; Department of Chemistry, Indiana University, Bloomington, IN 47405.
  • Gelfanov V; Department of Cell Signaling, de Duve Institute, B-1200 Brussels, Belgium.
  • Pan H; Department of Stem Cell Research, Novo Nordisk A/S, DK-2760 Måløv, Denmark.
  • DiMarchi R; Department of Chemistry, Indiana University, Bloomington, IN 47405.
  • Kahn CR; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
Proc Natl Acad Sci U S A ; 115(10): 2461-2466, 2018 03 06.
Article em En | MEDLINE | ID: mdl-29467286
Viruses are the most abundant biological entities and carry a wide variety of genetic material, including the ability to encode host-like proteins. Here we show that viruses carry sequences with significant homology to several human peptide hormones including insulin, insulin-like growth factors (IGF)-1 and -2, FGF-19 and -21, endothelin-1, inhibin, adiponectin, and resistin. Among the strongest homologies were those for four viral insulin/IGF-1-like peptides (VILPs), each encoded by a different member of the family Iridoviridae VILPs show up to 50% homology to human insulin/IGF-1, contain all critical cysteine residues, and are predicted to form similar 3D structures. Chemically synthesized VILPs can bind to human and murine IGF-1/insulin receptors and stimulate receptor autophosphorylation and downstream signaling. VILPs can also increase glucose uptake in adipocytes and stimulate the proliferation of fibroblasts, and injection of VILPs into mice significantly lowers blood glucose. Transfection of mouse hepatocytes with DNA encoding a VILP also stimulates insulin/IGF-1 signaling and DNA synthesis. Human microbiome studies reveal the presence of these Iridoviridae in blood and fecal samples. Thus, VILPs are members of the insulin/IGF superfamily with the ability to be active on human and rodent cells, raising the possibility for a potential role of VILPs in human disease. Furthermore, since only 2% of viruses have been sequenced, this study raises the potential for discovery of other viral hormones which, along with known virally encoded growth factors, may modify human health and disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Vírus / Fator de Crescimento Insulin-Like I / Receptor IGF Tipo 1 / Interações Hospedeiro-Patógeno / Insulina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Vírus / Fator de Crescimento Insulin-Like I / Receptor IGF Tipo 1 / Interações Hospedeiro-Patógeno / Insulina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article