A case of probable trimethoprim-sulfamethoxazole induced circulating antineutrophil cytoplasmic antibody-positive small vessel vasculitis.
Dermatol Online J
; 23(8)2017 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-29469750
ABSTRACT
Cutaneous leukocytoclastic vasculitis (LCV) can occur as skin-limited disease or as part a systemic vasculitis. Appropriate workup includes the evaluation of antineutrophil cytoplasmic antibodies (ANCAs), with a positive titer raising concern for the associated primary vasculitides including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA). In the absence of systemic findings, however, a drug etiology must also be considered. Tumor necrosis factor (TNF) inhibitors, propylthiouracil, levamisole-adulterated cocaine, hydralazine, and minocycline have been previously documented to induce ANCA-positive vasculitis (APV), which may present with conspicuously high ANCA titers. Herein we report trimethoprim-sulfamethoxazole as another culprit in drug-induced APV. Our case reinforces the need to consider drug etiology for APV and cautions against interpreting positive ANCAs as equivalent to evidence of systemic disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Combinação Trimetoprima e Sulfametoxazol
/
Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos
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Antibacterianos
Limite:
Aged80
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Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article