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Unexplored therapeutic opportunities in the human genome.
Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren; Campbell, Allen; Gan, Gregory N; Gaulton, Anna; Gomez, Shawn M; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L; Karlson, Anneli; Leach, Andrew R; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Stephen L; McManus, Michael T; Meehan, Terrence F; von Mering, Christian; Muthas, Daniel; Nguyen, Dac-Trung; Overington, John P; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L; Schürer, Stephan C; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Westergaard, David; Yang, Jeremy J; Zahoránszky-Köhalmi, Gergely.
Afiliação
  • Oprea TI; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Bologa CG; UNM Comprehensive Cancer Center, Albuquerque, NM, USA.
  • Brunak S; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  • Campbell A; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gan GN; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Gaulton A; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gomez SM; IQVIA, Plymouth Meeting, PA, USA.
  • Guha R; UNM Comprehensive Cancer Center, Albuquerque, NM, USA.
  • Hersey A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Holmes J; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, USA.
  • Jadhav A; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Jensen LJ; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
  • Johnson GL; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Karlson A; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Leach AR; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
  • Ma'ayan A; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Malovannaya A; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Mani S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Mathias SL; SciBite Limited, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • McManus MT; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Meehan TF; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • von Mering C; Baylor College of Medicine, Houston, TX, USA.
  • Muthas D; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Nguyen DT; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Overington JP; University of California, San Francisco, CA, USA.
  • Papadatos G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Qin J; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
  • Reich C; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
  • Roth BL; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
  • Schürer SC; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Simeonov A; Medicines Discovery Catapult, Alderley Edge, UK.
  • Sklar LA; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Southall N; GlaxoSmithKline, Stevenage, UK.
  • Tomita S; Baylor College of Medicine, Houston, TX, USA.
  • Tudose I; IQVIA, Cambridge, MA, USA.
  • Ursu O; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Vidovic D; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA.
  • Waller A; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
  • Westergaard D; UNM Comprehensive Cancer Center, Albuquerque, NM, USA.
  • Yang JJ; Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA.
  • Zahoránszky-Köhalmi G; Department of Pathology, University of New Mexico, Albuquerque, NM, USA.
Nat Rev Drug Discov ; 17(5): 317-332, 2018 05.
Article em En | MEDLINE | ID: mdl-29472638
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article