Manganese-Catalyzed Carbonylative Annulations for Redox-Neutral Late-Stage Diversification.
Angew Chem Int Ed Engl
; 57(19): 5384-5388, 2018 05 04.
Article
em En
| MEDLINE
| ID: mdl-29474755
An inexpensive, nontoxic manganese catalyst enabled unprecedented redox-neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious-metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late-stage manipulations under racemization-free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article