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Detection of novel RNA viruses from free-living gorillas, Republic of the Congo: genetic diversity of picobirnaviruses.
Duraisamy, Raja; Akiana, Jean; Davoust, Bernard; Mediannikov, Oleg; Michelle, Caroline; Robert, Catherine; Parra, Henri-Joseph; Raoult, Didier; Biagini, Philippe; Desnues, Christelle.
Afiliação
  • Duraisamy R; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. raja_king2k@yahoo.com.
  • Akiana J; Laboratoire national de santé publique, Brazzaville, Republic of the Congo.
  • Davoust B; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
  • Mediannikov O; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
  • Michelle C; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
  • Robert C; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
  • Parra HJ; Laboratoire national de santé publique, Brazzaville, Republic of the Congo.
  • Raoult D; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
  • Biagini P; Unité Mixte de Recherche 7268 ADES, Etablissement Français du Sang, Marseille, France.
  • Desnues C; Aix-Marseille Université, CNRS 7278, IRD 198, INSERM 1095, Assistance-Publique des Hôpitaux de Marseille, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. christelle.desnues@univ-amu.fr
Virus Genes ; 54(2): 256-271, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29476397
Most of the emerging infectious diseases reported so far originated in wildlife. Therefore, virological surveillance of animals and particularly great apes is of great interest to establish the repertory of viruses associated with healthy hosts. This will further help to identify the emergence of new viruses and predict the possibility of interspecies transmission. In this study, we performed shotgun viral metagenomics on stool samples collected from seventeen free-living wild gorillas from the Republic of the Congo. The analysis revealed the presence of novel RNA viruses (picobirnaviruses, partitivirus, and Picornavirales (posa-like and dicistrovirus-like viruses)). Among these, picobirnavirus-related sequences were abundantly covered in the stools. Based on genetic variations both in capsid and RdRp proteins of picobirnaviruses, at least 96 variants were identified and most of them were novel. Among the 96, 22 variants had a nearly complete genome or segment. A comprehensive sequence analysis identified a potential new genogroup/genetic cluster and the presence of a short linear amino acid motif (ExxRxNxxxE) in a hypothetical protein. The sequence analysis of posa-like virus and dicistrovirus showed that these two viruses were novel members in the respective viral families. In conclusion, the identification of novel RNA viruses and their genetic diversity increases our knowledge about viruses that are associated with stools of wild gorillas and contributes to the initiatives in the search for potential emerging zoonotic viruses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus de RNA / Vírus de RNA / Variação Genética / Doenças dos Primatas / Gorilla gorilla Tipo de estudo: Diagnostic_studies Limite: Animals País/Região como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus de RNA / Vírus de RNA / Variação Genética / Doenças dos Primatas / Gorilla gorilla Tipo de estudo: Diagnostic_studies Limite: Animals País/Região como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article