Primitive Endoderm Differentiation: From Specification to Epithelialization.
Curr Top Dev Biol
; 128: 81-104, 2018.
Article
em En
| MEDLINE
| ID: mdl-29477172
ABSTRACT
At the time of implantation, the mouse blastocyst has developed three cell lineages the epiblast (Epi), the primitive endoderm (PrE), and the trophectoderm (TE). The PrE and TE are extraembryonic tissues but their interactions with the Epi are critical to sustain embryonic growth, as well as to pattern the embryo. We review here the cellular and molecular events that lead to the production of PrE and Epi lineages and discuss the different hypotheses that are proposed for the induction of these cell types. In the second part, we report the current knowledge about the epithelialization of the PrE.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Padronização Corporal
/
Endoderma
/
Epitélio
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article