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Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances.
Parmar, Katrin; Banwell, Brenda L; Akbar, Nadine; Bigi, Sandra.
Afiliação
  • Parmar K; Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Banwell BL; Division of Neurology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
  • Akbar N; School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada.
  • Bigi S; Division of Child Neurology, Department of Pediatrics, University Children's Hospital Bern, University of Bern, Bern, Switzerland.
Neuropediatrics ; 49(3): 165-172, 2018 06.
Article em En | MEDLINE | ID: mdl-29482255
ABSTRACT
Pediatric onset multiple sclerosis (POMS) is a rare disease with an incidence of 0.07 to 2.9/100'000 children per year. It follows a relapsing-remitting disease course and is characterized by rapid accrual of inflammatory lesions, high relapse frequency, and early cognitive impairment. Magnetic resonance imaging (MRI) plays a pivotal role in the diagnosis of POMS, and in the exclusion of other disorders mimicking POMS. Furthermore, MRI aids in disease monitoring, and in the evaluation of therapeutic efficacy in both clinical practice and clinical trials. Volumetric MRI studies, diffusion tensor imaging, resting-state, and task-based functional MRI provide deeper insight into the impact of POMS on maturing neural networks. This review article aims to highlight the importance of MRI in the care of POMS patients and to provide an overview on the different MRI techniques used in the management of POMS.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Esclerose Múltipla Limite: Child / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Esclerose Múltipla Limite: Child / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article