Your browser doesn't support javascript.
loading
Interferometric mapping of material properties using thermal perturbation.
Goetz, Georges; Ling, Tong; Gupta, Tushar; Kang, Seungbum; Wang, Jenny; Gregory, Patrick D; Park, B Hyle; Palanker, Daniel.
Afiliação
  • Goetz G; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305; ggoetz@alumni.stanford.edu tongling@stanford.edu palanker@stanford.edu.
  • Ling T; Department of Neurosurgery, Stanford University, Stanford, CA 94305.
  • Gupta T; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305; ggoetz@alumni.stanford.edu tongling@stanford.edu palanker@stanford.edu.
  • Kang S; Department of Ophthalmology, Stanford University, Stanford, CA 94305.
  • Wang J; Department of Electrical Engineering, Stanford University, Stanford, CA 94305.
  • Gregory PD; Department of Ophthalmology and Visual Science, The Catholic University of Korea, Seoul 06591, Republic of Korea.
  • Park BH; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305.
  • Palanker D; Department of Applied Physics, Stanford University, Stanford, CA 94305.
Proc Natl Acad Sci U S A ; 115(11): E2499-E2508, 2018 03 13.
Article em En | MEDLINE | ID: mdl-29483276
ABSTRACT
Optical phase changes induced by transient perturbations provide a sensitive measure of material properties. We demonstrate the high sensitivity and speed of such methods, using two interferometric techniques quantitative phase imaging (QPI) in transmission and phase-resolved optical coherence tomography (OCT) in reflection. Shot-noise-limited QPI can resolve energy deposition of about 3.4 mJ/cm2 in a single pulse, which corresponds to 0.8 °C temperature rise in a single cell. OCT can detect deposition of 24 mJ/cm2 energy between two scattering interfaces producing signals with about 30-dB signal-to-noise ratio (SNR), and 4.7 mJ/cm2 when SNR is 45 dB. Both techniques can image thermal changes within the thermal confinement time, which enables accurate single-shot mapping of absorption coefficients even in highly scattering samples, as well as electrical conductivity and many other material properties in biological samples at cellular scale. Integration of the phase changes along the beam path helps increase sensitivity, and the signal relaxation time reveals the size of hidden objects. These methods may enable multiple applications, ranging from temperature-controlled retinal laser therapy or gene expression to mapping electric current density and characterization of semiconductor devices with rapid pump-probe measurements.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Tomografia de Coerência Óptica / Interferometria Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Tomografia de Coerência Óptica / Interferometria Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article