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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.
Zhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael E; Riddell, Imogen A; Yilmaz, Ömer H; Lippard, Stephen J.
Afiliação
  • Zhou W; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. lippard@mit.edu and The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Tehcnology, Cambridge, MA 02139, USA. ohyilmaz@mit.edu.
  • Almeqdadi M; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Tehcnology, Cambridge, MA 02139, USA. ohyilmaz@mit.edu.
  • Xifaras ME; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Tehcnology, Cambridge, MA 02139, USA. ohyilmaz@mit.edu.
  • Riddell IA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. lippard@mit.edu.
  • Yilmaz ÖH; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Tehcnology, Cambridge, MA 02139, USA. ohyilmaz@mit.edu.
  • Lippard SJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. lippard@mit.edu.
Chem Commun (Camb) ; 54(22): 2788-2791, 2018 Mar 13.
Article em En | MEDLINE | ID: mdl-29484327
ABSTRACT
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organoplatínicos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organoplatínicos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article