Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells.

Li, Xiaojin; Xu, Anjian; Li, Huihui; Zhang, Bei; Cao, Bangwei; Huang, Jian

Li, Xiaojin; Xu, Anjian; Li, Huihui; Zhang, Bei; Cao, Bangwei; Huang, Jian.

Afiliação

Li X; Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xu A; Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Li H; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhang B; Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Cao B; Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: oncologychina@163.com.
Huang J; Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: huangj1966@hotmail.com.

Biochim Biophys Acta Mol Basis Dis ; 1864(5 Pt A): 1693-1701, 2018 May.

Article em En | MEDLINE | ID: mdl-29486282

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas/tratamento farmacológico; Proteínas Tirosina Quinases/antagonistas & inibidores; Piridinas/farmacologia; Animais; Carcinoma Hepatocelular/enzimologia; Carcinoma Hepatocelular/patologia; Células Hep G2; Humanos; Neoplasias Hepáticas/enzimologia; Neoplasias Hepáticas/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Apatinib; Hepatocellular carcinoma; Signaling pathway; Targeted therapy; Tyrosine kinase inhibitor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Proteínas Tirosina Quinases / Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google