Cellular quiescence: How TGFß protects cancer cells from chemotherapy.
Mol Cell Oncol
; 5(2): e1413495, 2018.
Article
em En
| MEDLINE
| ID: mdl-29487897
ABSTRACT
Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFß signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFß/Smad signaling can't enter quiescence and subsequently die from chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article