Amiodarone affects Ebola virus binding and entry into target cells.
New Microbiol
; 41(2): 162-164, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29498743
ABSTRACT
Ebola Virus Disease is one of the most lethal transmissible infections characterized by a high fatality rate. Several research studies have aimed to identify effective antiviral agents. Amiodarone, a drug used for the treatment of arrhythmias, has been shown to inhibit filovirus infection in vitro by acting at the early step of the viral replication cycle. Here we demonstrate that amiodarone reduces virus binding to target cells and slows down the progression of the viral particles along the endocytic pathway. Overall our data support the notion that amiodarone interferes with Ebola virus infection by affecting cellular pathways/ targets involved in the viral entry process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ebolavirus
/
Ligação Viral
/
Internalização do Vírus
/
Amiodarona
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article