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Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.
Norcliffe, Jennifer L; Mina, John G; Alvarez, Emilio; Cantizani, Juan; de Dios-Anton, Francisco; Colmenarejo, Gonzalo; Valle, Silva Gonzalez-Del; Marco, Maria; Fiandor, José M; Martin, Julio J; Steel, Patrick G; Denny, Paul W.
Afiliação
  • Norcliffe JL; Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
  • Mina JG; Department of Chemistry, Durham University, Stockton Road, Durham, DH1 3LE, UK.
  • Alvarez E; Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
  • Cantizani J; Department of Chemistry, Durham University, Stockton Road, Durham, DH1 3LE, UK.
  • de Dios-Anton F; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Colmenarejo G; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Valle SG; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Marco M; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Fiandor JM; Biostatistics and Bioinformatics Unit, IMDEA Food Institute, CEI UAM and CSIC, Carretera de Cantoblanco 8, 28049, Madrid, Spain.
  • Martin JJ; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Steel PG; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
  • Denny PW; GlaxoSmithKline Investigacion y Desarrollo, Parque Tecnologico de Madrid, 28760, Tres Cantos, Madrid, Spain.
Sci Rep ; 8(1): 3938, 2018 03 02.
Article em En | MEDLINE | ID: mdl-29500420
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Glicoesfingolipídeos / Inibidores Enzimáticos / Leishmania / Antiprotozoários Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Glicoesfingolipídeos / Inibidores Enzimáticos / Leishmania / Antiprotozoários Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article