Application of Ultra-Centrifugation and Bench-Top <sup>19</sup>F NMR for Measuring Drug Phase Partitioning for the Ophthalmic Oil-in-Water Emulsion Products.

Wang, Xinyi; Patil, Sharadrao M; Keire, David A; Xu, Xiaoming; Chen, Kang

Application of Ultra-Centrifugation and Bench-Top ¹⁹F NMR for Measuring Drug Phase Partitioning for the Ophthalmic Oil-in-Water Emulsion Products.

Wang, Xinyi; Patil, Sharadrao M; Keire, David A; Xu, Xiaoming; Chen, Kang.

Afiliação

Wang X; Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, 20993, USA.
Patil SM; Center for Intelligent Chemical Instrumentation, Clippinger Laboratories, Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, 45701-2979, USA.
Keire DA; Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, 20993, USA.
Xu X; Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, St. Louis, Missouri, 63110, USA.
Chen K; Division of Product Quality and Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, 20993, USA.

AAPS PharmSciTech ; 19(4): 1647-1651, 2018 May.

Article em En | MEDLINE | ID: mdl-29500761

Assuntos

Imagem por Ressonância Magnética de Flúor-19/métodos; Fluprednisolona/análogos & derivados; Espectroscopia de Ressonância Magnética/métodos; Absorção Ocular; Ultracentrifugação/métodos; Água/análise; Emulsões; Fluprednisolona/análise; Fluprednisolona/química; Micelas; Tamanho da Partícula; Reprodutibilidade dos Testes; Tensoativos/análise; Tensoativos/química; Água/química

Palavras-chave

API; NMR; distribution; durezol; phase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ultracentrifugação / Fluprednisolona / Água / Espectroscopia de Ressonância Magnética / Imagem por Ressonância Magnética de Flúor-19 / Absorção Ocular Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google