The role of mitochondria in cellular toxicity as a potential drug target.

ABSTRACT

Mitochondrial malfunction is related to aging and to the onset of many diseases, such as obesity/diabetes, cancer, and cardiovascular and neurodegenerative diseases. The molecular principles of biological and toxicological processes the mitochondria can regulate should be disease-specific, cell type-specific, and drug targetable. Mitochondrial biology and toxicology is evolving and undergoing a revolution through fast-developing biotechnologies garnering increasing attention due to the importance of targeted therapies. Mitochondrial energy production and metabolism are conducted via post-mitochondrial signaling, and are controlled by extra-mitochondrial pathways. Mitochondrial biology and toxicology has a history spanning over 30 years and is one of the main scientific focuses at Cell Biology and Toxicology. It is our aim to pioneer innovations of mitochondrial biology and toxicology to improve the understanding, highlight the latest development, and find mitochondria-based targets for therapies. It is expected to know how drugs can initiate mitochondrial dysfunction, the role of nuclear messages in regulating mitochondrial DNA (MtDNA), and how mitochondria communicate between or with other cells. Further studies are crucial to discover how mitochondria control the process of immune response, autophagy/mitophagy, genome activation, and cell interaction. It is also needed to innovate how the transcription is started and terminated within mitochondria, the cytosolic proteins and other organelles interact with mitochondria, and MtDNA regulates the function of mitochondrial respiratory megacomplexes.