TREM2 and Amyloid Beta: A Love-Hate Relationship.

Udeochu, Joe; Sayed, Faten A; Gan, Li

Udeochu, Joe; Sayed, Faten A; Gan, Li.

Afiliação

Udeochu J; Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Sayed FA; Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Gan L; Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA. Electronic address: lgan@gladstone.ucsf.edu.

Neuron ; 97(5): 991-993, 2018 03 07.

Article em En | MEDLINE | ID: mdl-29518360

RESUMO

Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aß to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aß-associated deficits.

Assuntos

Doença de Alzheimer/genética; Peptídeos beta-Amiloides/genética; Animais; Dosagem de Genes; Humanos; Glicoproteínas de Membrana/genética; Camundongos; Microglia; Fenótipo; Receptores Imunológicos/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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