Tyrosinase Inhibitors from the Aerial Parts of Wulfenia carinthiaca Jacq.
Chem Biodivers
; 15(4): e1800014, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29521030
ABSTRACT
Activity guided isolation of a MeOH extract of the aerial plant parts of Wulfenia carinthiaca Jacq. (Plantaginaceae), using a mushroom tyrosinase assay, resulted in the isolation of five phenylethanoid glucosides and four iridoid glycosides. Two of them, 2'-O-acetylisoplantamajoside and 2',6â³-O-diacetylisoplantamajoside, represent new natural products. Evaluation of the inhibitory activity of all isolated compounds revealed that the observed activity is not related to the isolated phenylethanoid glycosides but mainly due to the presence of the iridoid glycoside globularin (IC50 41.94 µm; CI95% ± 16.61/11.89 µm). Interestingly, structurally close related compounds (globularicisin, baldaccioside, and isoscrophularioside) showed no or only a weak tyrosinase inhibitory activity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monofenol Mono-Oxigenase
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Componentes Aéreos da Planta
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Inibidores Enzimáticos
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Plantaginaceae
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article