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Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.
Rey, Felix A; Lok, Shee-Mei.
Afiliação
  • Rey FA; Institut Pasteur, Structural Virology Unit, CNRS UMR3569, 25-28 rue du Dr. Roux, 75015 Paris, France. Electronic address: felix.rey@pasteur.fr.
  • Lok SM; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore AND Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.
Cell ; 172(6): 1319-1334, 2018 03 08.
Article em En | MEDLINE | ID: mdl-29522750
ABSTRACT
Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process catalyzed by a specialized membrane-fusion protein expressed on their surface. This review focuses on recent structural studies of viral fusion proteins with an emphasis on their metastable prefusion form and on interactions with neutralizing antibodies. The fusion glycoproteins have been difficult to study because they are present in a labile, metastable form at the surface of infectious virions. Such metastability is a functional requirement, allowing these proteins to refold into a lower energy conformation while transferring the difference in energy to catalyze the membrane fusion reaction. Structural studies have shown that stable immunogens presenting the same antigenic sites as the labile wild-type proteins efficiently elicit potently neutralizing antibodies, providing a framework with which to engineer the antigens for stability, as well as identifying key vulnerability sites that can be used in next-generation subunit vaccine design.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Viroses / Vacinas Virais / Vacinas Sintéticas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Viroses / Vacinas Virais / Vacinas Sintéticas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article