[Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI]. / Dosierung von Antiinfektiva bei Nierenversagen und Nierenersatztherapie in der Intensivmedizin : Empfehlungen der Sektionen Niere der DGIIN, ÖGIAIN und DIVI.
Med Klin Intensivmed Notfmed
; 113(5): 384-392, 2018 06.
Article
em De
| MEDLINE
| ID: mdl-29546450
ABSTRACT
BACKGROUND:
Many anti-infective drugs require dose adjustments in critically ill patients with acute kidney injury (AKI) and renal replacement therapy, in order to achieve adequate therapeutic drug concentrations.OBJECTIVES:
The fundamental pharmacokinetic and pharmacodynamic principles of drug dose adjustment are presented. Recommendations on anti-infective drug dosage in intensive care are provided. MATERIALS ANDMETHODS:
We established dose recommendations of selected anti-infective drugs based on information in the summary of product characteristics, published studies and recommendations, pharmacokinetic and pharmacodynamic considerations, and the experience and expert opinion of the authors.RESULTS:
Out of a total of 37 anti-infective drugs (31 antibiotics, 2 antivirals, 4 antifungals) 8 can be administered independent of renal function. For 29 anti-infective drugs, a specific recommendation on drug dosage could be made in case of intermittent hemodialysis and for 24 anti-infective drugs in case of continuous hemo(dia)filtration.CONCLUSIONS:
Recommendations on dosing of important anti-infective drugs in critically ill patients with AKI and renal replacement therapy are provided.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia de Substituição Renal
/
Injúria Renal Aguda
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
De
Ano de publicação:
2018
Tipo de documento:
Article