Absolute Configuration of the Cytotoxic Marine Alkaloid Monanchocidin A.

Shubina, Larisa K; Makarieva, Tatyana N; Guzii, Alla G; Denisenko, Vladimir A; Popov, Roman S; Dmitrenok, Pavel S; Stonik, Valentin A

Shubina, Larisa K; Makarieva, Tatyana N; Guzii, Alla G; Denisenko, Vladimir A; Popov, Roman S; Dmitrenok, Pavel S; Stonik, Valentin A.

Afiliação

Shubina LK; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Makarieva TN; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Guzii AG; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Denisenko VA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Popov RS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Dmitrenok PS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Stonik VA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.

J Nat Prod ; 81(4): 1113-1115, 2018 04 27.

Article em En | MEDLINE | ID: mdl-29553737

RESUMO

The absolute configuration of the cytotoxic guanidine alkaloid monanchocidin A with 11 stereogenic centers from the marine sponge Monanchora pulchra was determined as 5 R, 8 S, 10 S, 13 R, 14 S, 15 R, 19 R, 23 R, 37 S, 42 S, 43 R after extensive reductive degradation and conversion of the resulting alcohols to MTPA derivatives.

Assuntos

Alcaloides/química; Organismos Aquáticos/química; Citotoxinas/química; Guanidina/análogos & derivados; Animais; Guanidina/química; Guanidinas/química; Poríferos/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Guanidina / Citotoxinas / Alcaloides / Organismos Aquáticos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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