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Isoflurane but Not Halothane Prevents and Reverses Helpless Behavior: A Role for EEG Burst Suppression?
Brown, P Leon; Zanos, Panos; Wang, Leiming; Elmer, Greg I; Gould, Todd D; Shepard, Paul D.
Afiliação
  • Brown PL; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
  • Zanos P; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland.
  • Wang L; University of Maryland School of Medicine, Baltimore, Maryland.
  • Elmer GI; Neuroscience Program, Maryland Psychiatric Research Center, Catonsville, Maryland.
  • Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
  • Shepard PD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Int J Neuropsychopharmacol ; 21(8): 777-785, 2018 08 01.
Article em En | MEDLINE | ID: mdl-29554264
ABSTRACT

BACKGROUND:

The volatile anesthetic isoflurane may exert a rapid and long-lasting antidepressant effect in patients with medication-resistant depression. The mechanism underlying the putative therapeutic actions of the anesthetic have been attributed to its ability to elicit cortical burst suppression, a distinct EEG pattern with features resembling the characteristic changes that occur following electroconvulsive therapy. It is currently unknown whether the antidepressant actions of isoflurane are shared by anesthetics that do not elicit cortical burst suppression.

METHODS:

In vivo electrophysiological techniques were used to determine the effects of isoflurane and halothane, 2 structurally unrelated volatile anesthetics, on cortical EEG. The effects of anesthesia with either halothane or isoflurane were also compared on stress-induced learned helplessness behavior in rats and mice.

RESULTS:

Isoflurane, but not halothane, anesthesia elicited a dose-dependent cortical burst suppression EEG in rats and mice. Two hours of isoflurane, but not halothane, anesthesia reduced the incidence of learned helplessness in rats evaluated 2 weeks following exposure. In mice exhibiting a learned helplessness phenotype, a 1-hour exposure to isoflurane, but not halothane, reversed escape failures 24 hours following burst suppression anesthesia.

CONCLUSIONS:

These results are consistent with a role for cortical burst suppression in mediating the antidepressant effects of isoflurane. They provide rationale for additional mechanistic studies in relevant animal models as well as a properly controlled clinical evaluation of the therapeutic benefits associated with isoflurane anesthesia in major depressive disorder.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Encéfalo / Anestésicos Inalatórios / Eletroencefalografia / Ondas Encefálicas / Halotano / Desamparo Aprendido / Isoflurano / Antidepressivos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Encéfalo / Anestésicos Inalatórios / Eletroencefalografia / Ondas Encefálicas / Halotano / Desamparo Aprendido / Isoflurano / Antidepressivos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article