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Acute and repeated dose 28-day oral toxicity of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) nanoparticles in Sprague-Dawley rats.
Leong, Yin-Hui; Isa, Anis Syaffini Mat; Mohamed Mahmood, Mazlianum; Moey, Chiew Erh Jacqueline; Utar, Zulkhurnain; Soon, Yong-Ing; Majid, Mohamed Isa Abd.
Afiliação
  • Leong YH; National Poison Centre, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia. Electronic address: yinhui_leong@yahoo.com.
  • Isa ASM; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia.
  • Mohamed Mahmood M; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia.
  • Moey CEJ; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia.
  • Utar Z; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia.
  • Soon YI; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia.
  • Majid MIA; National Poison Centre, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia.
Regul Toxicol Pharmacol ; 95: 280-288, 2018 Jun.
Article em En | MEDLINE | ID: mdl-29567329
This study aimed to investigate the oral acute and subacute toxicity of Poly [3-hydroxybutyrate-co-4-hydroxybutyrate], P(3HB-co-4HB) in the form of nanoparticles in Sprague-Dawley rats. Acute oral administration of P(3HB-co-4HB) nanoparticles was performed as a single dose up to 2000 mg/kg in six female rats for 14 days. Subacute toxicity study via oral administration for 28 days at doses of 0 (control), 500, 1000 and 2000 mg/kg in rats (10 rats in each group, female:male = 1:1) was conducted. The estimated lethal dose (LD50) of P(3HB-co-4HB) nanoparticles was >2000 mg/kg. No mortality, unusual changes in behaviour, adverse clinical signs, abnormal changes in body weights or food consumption were observed on all animals treated with P(3HB-co-4HB) nanoparticles during 14 days of the acute toxicity study. In the subacute test, there was no mortality and toxicologically significant changes in clinical signs, body weights, food consumption, hematology, clinical biochemistry, urinalysis, macroscopic findings, organ weights as well as histopathological examination were observed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Nanopartículas / Hidroxibutiratos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Nanopartículas / Hidroxibutiratos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article